![]() Schmoll HJ, Van Cutsem E, Stein A, Valentini V, Glimelius B, Haustermans K, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Thus, measuring and targeting CACClnc and its associated pathway could yield valuable insight into clinical management and might ameliorate CRC patients’ outcomes.īray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. In addition, expression of exosomal CACClnc in peripheral plasma of CRC patients can effectively predict the chemotherapy effect of patients before treatment. Mechanistically, CACClnc specifically bound to Y-box binding protein 1 (YB1, a splicing factor) and U2AF65 (a subunit of U2AF splicing factor), promoting the interaction between YB1 and U2AF65, and then modulated alternative splicing (AS) of RAD51 mRNA, and consequently altered CRC cell biology. CACClnc promoted CRC resistance to chemotherapy via promoting DNA repair and enhancing homologous recombination in vitro and in vivo. In this study, we identified a novel lncRNA, CACClnc, which was upregulated and associated with chemoresistance and poor prognosis in colorectal cancer (CRC). However, the effect of lncRNA on chemoresistance and RNA alternative splicing remains largely unknown. Still, crimp connectors are meant for stranded speaker wire-not solid core wire.Long non-coding RNAs (lncRNAs) play important roles in carcinogenesis. Plus, most provide a weatherproof seal, which is desirable when installing outdoor speakers. Crimp connectors are durable, easy to use, and effective. The better option is an in-line electrical crimp connector (also known as a "butt" connector). However, tape wears out over time, and the smallest tug on the wires can separate the connection. One way is to twist speaker wires together and use electrical tape. There are a couple of ways to splice speaker wires. You could cut and install new speaker wire, but why toss out functional wire when splicing gains the extra feet without the waste? Rearranging living areas is a great way to open up space, but it may mean relocating speakers and home theater equipment. Repeat this process with the positive ends of the bare wire with another crimp connector. If you want to double-check the electrical connection, use a battery for a quick test. Gently tug on the speaker wires to ensure that they hold fast. Do this once more for the other bare wire. (Double-check that it matches the gauge.) Using the crimping section of the wire cutters (it should be marked so that you correctly match the gauge), firmly squeeze the connector so that the connector's metal tubing shuts close around one of the bare wires. Take both negative ends of bare wire and insert them into opposite sides of a crimp connector. You can separate the individual wires (positive and negative terminals) by an inch, so you have room to work with them. Using the wire cutters, strip off the exterior jacket/insulation so that all four ends have a quarter-inch of exposed copper wire. If you're unsure, test the speaker wires with a battery. Take one set of wires that you intend to splice and place the ends/terminals next to each other-negative to negative (-), positive to positive (+). Repeat this process with any remaining speakers on the list. Label the pairs of wires, set them aside, and cross the speaker off your notes. Give yourself an extra inch or so and make the cut using the wire strippers. This is how much you'll cut from the spool of speaker wire. ![]() Calculate the difference between the length of wire you have versus what the speaker needs. Cross those speakers off your notes so that you know they've been accounted for.Ĭhoose any remaining wire and assign it to a speaker with a label. If you have wires that don't need splicing, label them with the assigned speaker and set them aside. ![]() Also, double-check that the wires are the proper gauge. There's a chance that some of those wires will be the right length. When finished, measure the speaker wire you set aside earlier and compare it to your notes. Write down the numbers along with the speaker location (for example, front left/right, center, or surround left/right) in a notepad. It's better to overestimate slightly than underestimate, as slack is easy to manage, and splicing involves a bit of trimming anyway. Use the measuring tape and tally the distances. After the speakers have been placed, determine the length of wire required to connect each speaker to the stereo system.
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